A selective inhibitor of MMP-2 and MMP-9
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SB-3CT

Item No. 16337

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[(4-phenoxyphenyl)sulfonyl]methyl]-thiirane
CAS Number
292605-14-2
Synonyms
  • Matrix Metalloproteinase-2/9 Inhibitor IV
  • MMP-2/MMP-9 Inhibitor IV
Molecular Formula
C15H14O3S2
Formula Weight
306.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7.2) (1:5): 0.1 mg/mlDMSO: 15 mg/mlEthanol: 2 mg/ml
λmax
244 nm
SMILES
O=S(C(C=C1)=CC=C1OC2=CC=CC=C2)(CC3SC3)=O
InChi Code
InChI=1S/C15H14O3S2/c16-20(17,11-14-10-19-14)15-8-6-13(7-9-15)18-12-4-2-1-3-5-12/h1-9,14H,10-11H2
InChi Key
LSONWRHLFZYHIN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    Product Description

    SB-3CT is a selective, mechanism-based inhibitor of the gelatinases, matrix metalloproteinase-2 (MMP-2) and MMP-9 (Kis = 28 and 400 nM, respectively).1,2 First pass metabolism of SB-3CT in vivo produces a monohydroxylated metabolite that has greater inhibitory activity (Kis = 6 and 160 nM for MMP-2 and MMP-9, respectively).2 Both SB-3CT and its active metabolite can cross the blood-brain barrier and have utility in diseases of the central nervous system, such as stroke and traumatic brain injury.2,3 SB-3CT may have applications in other pathologies involving gelatinases, including cancer, cardiovascular diseases, and inflammation.4,5

    WARNING This product is not for human or veterinary use.