SR 11302

SR 11302 is a synthetic retinoid that inhibits AP-1 activity without activating transcription through RARE.¹ It significantly suppresses both AP-1 activation and phorbol ester-induced papilloma formation in mice when applied topically (0.1 µM).² SR 11302 is used to elucidate the role of AP-1 in various signaling pathways.^3,4

WARNING This product is not for human or veterinary use.

1. Fanjul, A., Dawson, M.I., Hobbs, P.D., et al. A new class of retinoids with selective inhibition of AP-1 inhibits proliferation. Nature 372(6501), 107-111 (1994).

2. Huang, C., Ma, W.Y., Dawson, M.I., et al. Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid. Proc. Natl. Acad. Sci. USA 94(11), 5826-5830 (1997).

3. Shiohara, M., Dawson, M.I., Hobbs, P.D., et al. Effects of novel RAR- and RXR-selective retinoids on myeloid leukemic proliferation and differentiation in vitro. Blood 93(6), 2057-2066 (1999).

4. Kankaanranta, H., Ilmarinen, P., Zhang, X., et al. Tumour necrosis factor-α regulates human eosinophil apoptosis via ligation of TNF-receptor 1 and balance between NF-κB and AP-1. PLoS One 9(2), e90298 (2014).