Pricing updated 2019-07-23. Prices are subject to change without notice.
4-Thiouridine (4-SU) is a photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling.1,2,3 The crosslinking thio moiety is attached directly to the nucleotide base, thus 4-SU differs from uridine only by a single sulfur substitution. This offers the advantage of incorporating into an RNA chain with minimal structural perturbation and with similar base-pairing properties, reducing the likelihood that substitution will impair RNA interactions or activities.3
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Burger, K., Mühl, B., Kellner, M., et al. 4-
Thomas, G., and Favre, A. 4-
3. Harris, M.E., and Christian, E.L. RNA crosslinking methods Methods in Enzymology 468, 127-146 (2009).