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4-Thiouridine

Item № 16373
CAS № 13957-31-8
Purity ≥98%
product image
                (CAS 13957-31-8)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     5 mg $29.00 0.00
     25 mg $94.00 0.00
     100 mg $319.00 0.00
     250 mg $653.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

Description
Synonyms
  • NSC 518132
  • 4-SU

4-Thiouridine (4-SU) is a photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling.1,2,3 The crosslinking thio moiety is attached directly to the nucleotide base, thus 4-SU differs from uridine only by a single sulfur substitution. This offers the advantage of incorporating into an RNA chain with minimal structural perturbation and with similar base-pairing properties, reducing the likelihood that substitution will impair RNA interactions or activities.3

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Technical Information
Formal Name
4-thio-uridine
CAS Number
13957-31-8
Synonyms
  • NSC 518132
  • 4-SU
Molecular Formula
C9H12N2O5S
Formula Weight
260.3
Purity
≥98%
Formulation
A crystalline solid
λmax
249, 330 nm
SMILES
OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=CC(NC2=O)=S)O1
InChI Code
InChI=1S/C9H12N2O5S/c12-3-4-6(13)7(14)8(16-4)11-2-1-5(17)10-9(11)15/h1-2,4,6-8,12-14H,3H2,(H,10,15,17)/t4-,6-,7-,8-/m1/s1
InChI Key
ZLOIGESWDJYCTF-XVFCMESISA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

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References & Product Citations
Product Description References

1. Burger, K., Mühl, B., Kellner, M., et al. 4-Thiouridine inhibits rRNA synthesis and causes a nucleolar stress response RNA Biol. 10(10), 1623-1630 (2013).

2. Thomas, G., and Favre, A. 4-Thiouridine triggers both growth delay induced by near-ultraviolet light and photoprotection European Journal of Biochemistry 113(1), 67-74 (1980).

3. Harris, M.E., and Christian, E.L. RNA crosslinking methods Methods in Enzymology 468, 127-146 (2009).

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