A photoreactive ribonucleotide analog
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4-Thiouridine

Item No. 16373

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-thio-uridine
CAS Number
13957-31-8
Synonyms
  • NSC 518132
  • 4-SU
Molecular Formula
C9H12N2O5S
Formula Weight
260.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 2 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
249, 330 nm
SMILES
OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=CC(NC2=O)=S)O1
InChi Code
InChI=1S/C9H12N2O5S/c12-3-4-6(13)7(14)8(16-4)11-2-1-5(17)10-9(11)15/h1-2,4,6-8,12-14H,3H2,(H,10,15,17)/t4-,6-,7-,8-/m1/s1
InChi Key
ZLOIGESWDJYCTF-XVFCMESISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $41

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    25 mg

    $132

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    100 mg

    $448

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    250 mg

    $917

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    Product Description

    4-Thiouridine (4-SU) is a photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling.1,2,3 The crosslinking thio moiety is attached directly to the nucleotide base, thus 4-SU differs from uridine only by a single sulfur substitution. This offers the advantage of incorporating into an RNA chain with minimal structural perturbation and with similar base-pairing properties, reducing the likelihood that substitution will impair RNA interactions or activities.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Burger, K., Mühl, B., Kellner, M., et al. 4-Thiouridine inhibits rRNA synthesis and causes a nucleolar stress response. RNA Biol. 10(10), 1623-1630 (2013).

    2. Thomas, G., and Favre, A. 4-Thiouridine triggers both growth delay induced by near-ultraviolet light and photoprotection. Eur. J. Biochem. 113(1), 67-74 (1980).

    3. Harris, M.E., and Christian, E.L. RNA crosslinking methods. Methods Enzymol. 468, 127-146 (2009).