An alkaline aluminum−sucrose complex
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Sucrose octasulfate (potassium salt)

Item No. 16382

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3,4,6-tetrakis(hydrogen sulfate),1,3,4,6-tetra-O-sulfo-β-D-fructofuranosyl α-D-glucopyranoside, octapotassium salt
CAS Number
73264-44-5
Synonyms
  • SOS
  • Sucrosofate potassium
Molecular Formula
C12H14O35S8 • 8K
Formula Weight
1287.5
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Water: 10 mg/mLWater: 10 mg/ml
SMILES
O=S(O[C@H]1[C@H](OS(=O)([O-])=O)[C@@H](COS(=O)([O-])=O)O[C@H](O[C@]2(COS(=O)([O-])=O)O[C@H](COS(=O)([O-])=O)[C@@H](OS(=O)([O-])=O)[C@@H]2OS(=O)([O-])=O)[C@@H]1OS(=O)([O-])=O)([O-])=O.[K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+]
InChi Code
InChI=1S/C12H22O35S8.8K/c13-48(14,15)37-1-4-6(43-51(22,23)24)8(45-53(28,29)30)9(46-54(31,32)33)11(40-4)42-12(3-39-50(19,20)21)10(47-55(34,35)36)7(44-52(25,26)27)5(41-12)2-38-49(16,17)18;;;;;;;;/h4-11H,1-3H2,(H,13,14,15)(H,16,17,18)(H,19,20,21)(H,22,2
InChi Key
XISWAUUBQBEDFB-OAHZNKFOSA-F
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

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    Product Description

    Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum−sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury.1 It can bind to exosite II of thrombin (KD = ~1.4 µM) and inhibit its catalytic activity (IC50 = 4.5 µM) and, as such, has been used as a surrogate for heparin.2 Furthermore, SOS has been shown to inhibit tumor growth in mouse melanoma and lung carcinoma models by preventing fibroblast growth factor 2 (FGF-2) binding to endothelial cells and also by removing any pre-bound FGF-2 from these cells (IC50 = ~2 µg/ml).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Furukawa, O., Matsui, H., and Suzuki, N. Effects of sucralfate and its components on acid- and pepsin-induced damage to rat gastric epithelial cells. Jpn. J. Pharmacol. 75(1), 21-25 (1997).

    2. Desai, B.J., Boothello, R.S., Mehta, A.Y., et al. Interaction of thrombin with sucrose octasulfate. Biochemistry 50(32), 6973-6982 (2011).

    3. Fannon, M., Forsten-Williams, K., Nugent, M.A., et al. Sucrose octasulfate regulates fibroblast growth factor-2 binding, transport, and activity: Potential for regulation of tumor growth. J. Cell Physiol. 215(2), 434-441 (2008).