An ecdysteroid hormone
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Ponasterone A

Item No. 16386

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5β)-2β,3β,14,20,22R-pentahydroxy-cholest-7-en-6-one
CAS Number
13408-56-5
Synonyms
  • 25-Deoxyecdysterone
Molecular Formula
C27H44O6
Formula Weight
464.6
Purity
≥95%
Formulation (Request formulation change)
A powder
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mLDMSO: 1 mg/mLEthanol: 5 mg/mLEthanol:PBS (pH 7.2)(1:2): 0.3 mg/mLMethanol: Soluble
SMILES
O=C1[C@]2([H])C[C@@H](O)[C@@H](O)C[C@]2(C)[C@]3([H])C([C@@](CC[C@]4([H])[C@]([C@H](O)CCC(C)C)(O)C)(O)[C@]4(C)CC3)=C1
InChi Code
InChI=1S/C27H44O6/c1-15(2)6-7-23(31)26(5,32)22-9-11-27(33)17-12-19(28)18-13-20(29)21(30)14-24(18,3)16(17)8-10-25(22,27)4/h12,15-16,18,20-23,29-33H,6-11,13-14H2,1-5H3/t16-,18-,20+,21-,22-,23+,24+,25+,26+,27+/m0/s1
InChi Key
PJYYBCXMCWDUAZ-JJJZTNILSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $69

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    5 mg

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    10 mg

    $461

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    25 mg

    $983

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    Product Description

    Ponasterone A is an analog of 20-hydroxy ecdysone (Item No. 16145), the insect steroid hormone that regulates the metamorphosis of Drosophila.1 Ecdysteroids such as this compound have been employed as inducers of ecdysone-inducible mammalian expression systems.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fallon, A.M., and Gerenday, A. Ecdysone and the cell cycle: Investigations in a mosquito cell line. J. Insect Physiol. 56(10), 1396-1401 (2010).

    2. Saez, E., Nelson, M.C., Eshelman, B., et al. Identification of ligands and coligands for the ecdysone-regulated gene switch. Proc. Natl. Acad. Sci. USA 97(26), 14512-14517 (2000).

    3. Karzenowski, D., Potter, D.W., and Padidam, M. Inducible control of transgene expression with ecdysone receptor: Gene switches with high sensitivity, robust expression, and reduced size. Biotechniques 39(2), 191-192 (2005).