A cytidine deaminase inhibitor
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Tetrahydrouridine

Item No. 16402

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4,5,6-tetrahydro-uridine
CAS Number
18771-50-1
Synonyms
  • NSC 112907
  • THU
Molecular Formula
C9H16N2O6
Formula Weight
248.2
Purity
≥90%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mLDMSO: 10 mg/mlPBS (pH 7.2): 5 mg/mL
SMILES
O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N2C(NC(O)CC2)=O
InChi Code
InChI=1S/C9H16N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h4-8,12-15H,1-3H2,(H,10,16)/t4-,5?,6-,7-,8-/m1/s1
InChi Key
UCKYOOZPSJFJIZ-XVKVHKPRSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $182

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    25 mg

    $340

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    50 mg

    $636

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    Cayman Chemical
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    Product Description

    Tetrahydrouridine is an inhibitor of cytidine deaminase (Kis = 54 and 240 nM for the human and E. coli enzymes, respectively).1,2 In vivo, tetrahydrouridine inhibits the metabolism of decitabine (Item No. 11166) and enhances decitabine-induced inhibition of tumor growth in a B16 murine melanoma model.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chabner, B.A., Johns, D.G., Coleman, C.N., et al. Purification and properties of cytidine deaminase from normal and leukemic granulocytes. J. Clin. Invest. 53(3), 922-931 (1974).

    2. Cohen, R.M., and Woldender, R. Cytidine deaminase from Escherichia coli. Purification, properties and inhibition by the potential transition state analog 3,4,5,6-tetrahydrouridine. The Journal of Biological Chemisty 246(24), 7561-7656 (1971).

    3. Alcazar, O., Achberger, S., Aldrich, W., et al. Epigenetic regulation by decitabine of melanoma differentiation in vitro and in vivo. Int. J. Cancer 131(1), 18-29 (2012).