A potent inhibitor of Mdm2-p53 interaction
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NSC 66811

Item No. 16431

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-methyl-7-[phenyl(phenylamino)methyl]-8-quinolinol
CAS Number
6964-62-1
Molecular Formula
C23H20N2O
Formula Weight
340.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 33 mg/mlDMF:PBS(pH7.2) (1:2): 0.3 mg/mlDMSO: 25 mg/mlEthanol: 1 mg/ml
λmax
251 nm
SMILES
CC1=NC2=C(O)C(C(NC3=CC=CC=C3)C4=CC=CC=C4)=CC=C2C=C1
InChi Code
InChI=1S/C23H20N2O/c1-16-12-13-18-14-15-20(23(26)22(18)24-16)21(17-8-4-2-5-9-17)25-19-10-6-3-7-11-19/h2-15,21,25-26H,1H3
InChi Key
WEENRMPCSWFMTE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    Product Description

    NSC 66811 is a potent inhibitor of murine double minute 2 (Mdm2) interaction with p53 by binding Mdm2 (Ki = 120 nM), in this way activating p53.1 NSC 66811 induces the accumulation of p21, p53, and Mdm2 in human colon cancer cells in vitro. Inhibitors of the Mdm2-p53 interaction, including NSC 66811, induce p53- and p21-dependent cell cycle arrest and p53-dependent cell death in tumor cell lines.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lu, Y., Nikolovska-Coleska, Z., Fang, X., et al. Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy. J. Med. Chem. 49(13), 3759-3762 (2006).

    2. Shangary, S., and Wang, S. Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: A novel approach for cancer therapy. Annu. Rev. Pharmacol. Toxicol. 49, 223-241 (2016).