An inhibitor of DAGL
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RHC-80267

Item No. 16432

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,1’-[O,O’-[1,6-hexanediylbis(iminocarbonyl)]dioxime]
CAS Number
83654-05-1
Synonyms
  • U-57908
Formula Weight
394.5
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 5 mg/mlEthanol: 5 mg/ml
SMILES
O=C(NCCCCCCNC(O/N=C1CCCCC/1)=O)O/N=C2CCCCC\2
InChi Code
InChI=1S/C20H34N4O4/c25-19(27-23-17-11-5-3-6-12-17)21-15-9-1-2-10-16-22-20(26)28-24-18-13-7-4-8-14-18/h1-16H2,(H,21,25)(H,22,26)
InChi Key
RXSVYGIGWRDVQC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $37

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    10 mg

    $59

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    25 mg

    $137

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    50 mg

    $237

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    Product Description

    RHC-80267 is an inhibitor of diacylglycerol lipase (DAGL; IC50 = 4 µM for the canine platelet enzyme).1 It also inhibits the serine hydrolases KIAA1363, fatty acid amide hydrolase (FAAH), BAT5, phospholipase A2 (PLA2), hormone-sensitive lipase (HSL), and acetylcholinesterase (AChE) by greater than 60% when used at a concentration of 50 µM.2 RHC-80267 (0.1-10 µM) potentiates ACh-induced relaxation of isolated rat mesenteric arteries.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sutherland, C.A., and Amin, D. Relative activities of rat and dog platelet phospholipase A2 and diglyceride lipase. Selective inhibition of diglyceride lipase by RHC 80267. The Journal of Biological Chemisty 257(23), 14006-14010 (2014).

    2. Hoover, H.S., Blankman, J.L., Niessen, S., et al. Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling. Bioorg. Med. Chem. Lett. 18(22), 5838-5841 (2008).

    3. Ghisdal, P., Vandenberg, G., Hamaide, M.-C., et al. The diacylglycerol lipase inhibitor RHC-80267 potentiates the relaxation to acetylcholine in rat mesenteric artery by anti-cholinesterase action. Eur. J. Pharmacol. 517(1-2), 97-102 (2005).

    Product Citations

    Lin, D.T.S., and Conibear, E. ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization. Elife 4, e11306 (2015).