A TP receptor agonist
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Isomer(s)
164425-trans U-44069
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U-44069

Item No. 16440

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9,11-dideoxy-9α,11α-epoxymethano-prosta-5Z,13E-dien-1-oic acid
CAS Number
56985-32-1
Synonyms
  • 9,11-dideoxy-9α,11α-epoxymethano PGF2α
  • 9,11-dideoxy-9α,11α-epoxymethano Prostaglandin F2α
  • 9,11-epoxymethano Prostaglandin H2
Molecular Formula
C21H34O4
Formula Weight
350.5
Purity
≥98%
Formulation
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: >100 mg/ml (from U-46619)DMSO: >100 mg/ml (from U-46619)Ethanol: >100mg/ml (from U-46619)PBS pH 7.2: >2 mg/ml (from U-46619)
SMILES
CCCCC[C@H](O)/C=C/[C@H]1C(CO2)CC2[C@@H]1C/C=C\CCCC(O)=O
InChi Code
InChI=1S/C21H34O4/c1-2-3-6-9-17(22)12-13-18-16-14-20(25-15-16)19(18)10-7-4-5-8-11-21(23)24/h4,7,12-13,16-20,22H,2-3,5-6,8-11,14-15H2,1H3,(H,23,24)/b7-4-,13-12+/t16?,17-,18-,19+,20?/m0/s1
InChi Key
DJKDIKIDYDXHDD-REGKDVDGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $160

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    5 mg

    $719

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    10 mg

    $1,276

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    Product Description

    U-44069 is a stable analog of the endoperoxide PGH2 (Item No. 17020) and a TP receptor agonist. It stimulates shape change in human platelets without a measurable increase in Ca2+ with an EC50 value of 1.8 nM.1 U-44069 has an EC50 value of 3 µM and 54 nM for platelet aggregation and phosphatidate formation in human platelets, respectively.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Simpson, A.W.M., Hallam, T.J., and Rink, T.J. Low concentrations of the stable prostaglandin endoperoxide U44069 stimulate shape change in quin2-loaded platelets without a measurable increase in [Ca2+]i. FEBS Lett. 201, 301-305 (1986).

    2. Pollock, W.K., Armstrong, R.A., Brydon, L.J., et al. Thromboxane-induced phosphatidate formation in human platelets. Relationship to receptor occupancy and to changes in cytosolic free calcium. Biochem. J. 219, 833-842 (1984).