A substrate for fatty acid synthase
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Malonyl Coenzyme A (lithium salt)

Item No. 16455

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
S-(hydrogen propanedioate) coenzyme A, lithium salt
CAS Number
108347-84-8
Synonyms
  • Malonyl-CoA
Molecular Formula
C24H38N7O19P3S • XLi
Formula Weight
853.6
Purity
≥90%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
257 nm
SMILES
O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CC(O)=O)=O)=O)=O)(O)=O)(O)=O)[C@H]1OP(O)(O)=O.[Li]
InChi Code
InChI=1S/C24H38N7O19P3S.Li/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31;/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41);/t12-,17-,18-,19+,23-;/m1./s1
InChi Key
OPIJLICRFQMMJH-CXIGZAHASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $54

    Add

    5 mg

    $121

    Add

    10 mg

    $216

    Add

    25 mg

    $472

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Malonyl coenzyme A is a coenzyme A (CoA; Item No. 16147) derivative that is used in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane.1,2 Malonyl-CoA is formed by acetyl-CoA carboxylase-mediated carboxylation of acetyl-CoA (Item No. 16160).1 Fatty acid synthase catalyzes the NADPH-dependent condensation of malonyl-CoA and acetyl-CoA to produce palmitate. Proliferating human cancer cells upregulate this fatty acid synthesis pathway as a strategy for survival. High levels of malonyl-CoA, achieved through fatty acid synthase inhibition, have been proposed to contribute to cancer cell apoptosis.3 Manlonyl-CoA is exclusively used as the extender unit in the synthesis of bacterial aromatic polyketides.2,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hiltunen, J.K., Autio, K.J., Schonauer, M.S., et al. Mitochondrial fatty acid synthesis and respiration. Biochim. Biophys. Acta 1797(6-7), 1195-1202 (2010).

    2. Summers, R.G., Ali, A., Shen, B., et al. Malonyl-coenzyme A:Acyl carrier protein acyltransferase of Streptomyces glaucescens: A possible link between fatty acid and polyketide biosynthesis. Biochem. 34(29), 9389-9402 (1995).

    3. Pizer, E.S., Thupari, J., Han, W.F., et al. Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts. Cancer Res. 60, 213-218 (2000).

    4. Zhan, J. Biosynthesis of bacterial aromatic polyketides. Curr. Top. Med. Chem. 9(17), 1598-1610 (2009).

    Product Citations

    Tagi, H., Qiu, C., Zeng, Y., et al. Serine supplementation suppresses hypoxia-induced pathological retinal angiogenesis. Theranostics 15(1), 5087-5105 (2025).