A long-acting ascorbic acid derivative
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L-Ascorbic Acid 2-phosphate (magnesium salt hydrate)

Item No. 16457

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(dihydrogen phosphate)-L-ascorbic acid, dimagnesium salt hydrate
CAS Number
1713265-25-8
Synonyms
  • AA2P
  • Ascorbyl PM
  • L-Ascorbic Acid 2-phosphate (magnesium salt)
  • Phospitan C
Molecular Formula
C6H9O9P • 1.5Mg [XH2O]
Formula Weight
292.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 1 mg/ml
λmax
259 nm
SMILES
O=C1C(OP(O)(O)=O)=C(O)[C@]([C@@H](O)CO)([H])O1.O=C2C(OP(O)(O)=O)=C(O)[C@]([C@@H](O)CO)([H])O2.[Mg].[Mg].[Mg].O
InChi Code
InChI=1S/6C6H9O9P.3Mg.H2O/c6*7-1-2(8)4-3(9)5(6(10)14-4)15-16(11,12)13;;;;/h6*2,4,7-9H,1H2,(H2,11,12,13);;;;1H2/t6*2-,4+;;;;/m000000..../s1
InChi Key
BIKWSUZBBSTDIN-QUJVRXEFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

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    10 g

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    50 g

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    Product Description

    L-Ascorbic acid 2-phosphate (AA2P) is a long-acting ascorbic acid derivative that stimulates collagen expression and formation and is used in human cell culture.1,2 It may be included in media to enhance the survival of human embryonic stem cells or increase the growth and replicative lifespan of human corneal endothelial cells.3,4 AA2P is also used to drive osteogenic differentiation in human adipose stem cells and in human mesenchymal stromal/stem cells.5,6,7

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kurata, S., and Hata, R. Epidermal growth factor inhibits transcription of type I collagen genes and production of type I collagen in cultured human skin fibroblasts in the presence and absence of L-ascorbic acid 2-phosphate, a long-acting vitamin C derivative. The Journal of Biological Chemisty 266(15), 9997-10003 (1991).

    2. Yoshikawa, K., Takahashi, S., Imamura, Y., et al. Secretion of non-helical collagenous polypeptides of α1(IV) and α2(IV) chains upon depletion of ascorbate by cultured human cells. J. Biochem. 129(6), 929-936 (2001).

    3. Furue, M.K., Na, J., Jackson, J.P., et al. Heparin promotes the growth of human embryonic stem cells in a defined serum-free medium. Proc. Natl. Acad. Sci. USA 105(36), 13409-13414 (2008).

    4. Kimoto, M., Shima, N., Yamaguchi, M., et al. Role of hepatocyte growth factor in promoting the growth of human corneal endothelial cells stimulated by L-ascorbic acid 2-phosphate. Invest. Ophthalmol. Vis. Sci. 53(12), 7583-7589 (2012).

    5. Kyllönen, L., Maimi, S., Mannerström, B., et al. Effects of different serum conditions on osteogenic differentiation of human adipose stem cells in vitro. Stem Cell Res.Ther. 4(1), 1-15 (2013).

    6. Fang, X., Murakami, H., Demura, S., et al. A novel method to apply osteogenic potential of adipose derived stem cells in orthopaedic surgery. PLoS One 9(2), 1-6 (2014).

    7. Mariner, P.D., Johannesen, E., and Anseth, K.S. Manipulation of miRNA activity accelerates osteogenic differentiation of hMSCs in engineered 3D scaffolds. J. Tissue Eng. Regen. Med. 6(4), 314-324 (2012).