A biotin labeling reagent
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Product Categories

Product Type

Biochemicals
Labeling & Detection

Research Area

3-[2-N-(Biotinyl)aminoethyldithio]propanoic Acid

Item No. 16461

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[2-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]ethyl]dithio]-propanoic acid
CAS Number
104582-29-8
Synonyms
  • SS-Biotin
Molecular Formula
C15H25N3O4S3
Formula Weight
407.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 25 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
SMILES
O=C1N[C@@]2([H])[C@@](CS[C@H]2CCCCC(NCCSSCCC(O)=O)=O)([H])N1
InChi Code
InChI=1S/C15H25N3O4S3/c19-12(16-6-8-25-24-7-5-13(20)21)4-2-1-3-11-14-10(9-23-11)17-15(22)18-14/h10-11,14H,1-9H2,(H,16,19)(H,20,21)(H2,17,18,22)/t10-,11-,14-/m0/s1
InChi Key
LUKYYZVIDAWYMZ-MJVIPROJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    10 mg

    $54

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    25 mg

    $120

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    50 mg

    $209

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    100 mg

    $341

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    Product Description

    3-[2-N-(Biotinyl)aminoethyldithio]propanoic acid features a biotin group and propanoic acid separated by a disulfide linkage. The carboxyl group of propanoic acid allows biotinylation of targets through either a chemical or enzymatic acylation reaction. The disulfide bond permits removal of the biotin group with reducing agents.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Citations

    Li, H., Frankenfield, A.M., Housten, R., et al. Thiol-cleavable biotin for chemical and enzymatic biotinylation and its application to mitochondrial TurboID proteomics. J. Am. Soc. Mass Spectrom. (2021).

    Kremer, D.M., Nelson, B.S., Lin, L., et al. GOT1 inhibition primes pancreatic cancer for ferroptosis through the autophagic release of labile iron. bioRxiv (2020).