A muscle relaxant
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Azumolene (sodium salt)

Item No. 16462

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[[[5-(4-bromophenyl)-2-oxazolyl]methylene]amino]-2,4-imidazolidinedione, monosodium salt
CAS Number
105336-14-9
Synonyms
  • EU4093
Molecular Formula
C13H8BrN4O3 • Na
Formula Weight
371.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 2 mg/ml
λmax
259, 338 nm
SMILES
BrC1=CC=C(C2=CN=C(/C=N/N3C([N-]C(C3)=O)=O)O2)C=C1.[Na+]
InChi Code
InChI=1S/C13H9BrN4O3.Na/c14-9-3-1-8(2-4-9)10-5-15-12(21-10)6-16-18-7-11(19)17-13(18)20;/h1-6H,7H2,(H,17,19,20);/q;+1/p-1/b16-6+;
InChi Key
PHJRJPWBPXLNAJ-FPUQOWELSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $178

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    10 mg

    $312

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    Product Description

    Azumolene is a muscle relaxant that inhibits the release of calcium from skeletal muscle sarcoplasmic reticulum.1,2 It inhibits a component of store-operated calcium entry (SOCE) that is coupled to the skeletal muscle ryanodine receptor, with 20 µM azumolene causing a 70% reduction in SOCE in myotubes.3,4 Azumolene has utility in countering muscle dysfunction associated with malignant hyperthermia.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Palnitkar, S.S., Michelson, J.R., Louis, C.F., et al. Pharmacological distinction between dantrolene and ryanodine binding sites: Evidence from normal and malignant hyperthermia-susceptible porcine skeletal muscle. Biochem. J. 326 (Pt 3), 847-852 (1997).

    2. Leslie, G.C., and Part, N.J. The effect of EU4093 (azumolene sodium) on the contraction of intrafusal muscle in the soleus muscle of the anaesthetized rat. Br. J. Pharmacol. 97(4), 1151-1156 (1989).

    3. Zhao, X., Weisleder, N., Han, X., et al. Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal muscle ryanodine receptor. The Journal of Biological Chemisty 281(44), 33477-33486 (2006).

    4. Yarotskyy, V., Protasi, F., and Dirksen, R.T. Accelerated activation of SOCE current in myotubes from two mouse models of anesthetic- and heat-induced sudden death. PLoS One 8(10), 1-12 (2013).