A spin label used in site-directed spin labeling
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Product Type

Biochemicals
Labeling & Detection
Reactive Probes

Research Area

Application

EPR/ESR

MTSSL

Item No. 16463

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,5-dihydro-2,2,5,5-tetramethyl-3-[[(methylsulfonyl)thio]methyl]-1H-pyrrol-1-yloxy
CAS Number
81213-52-7
Molecular Formula
C10H18NO3S2
Formula Weight
264.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF: 30 mg/mlDMSO: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/mlEthanol: 15 mg/mlEthanol: 15 mg/ml
SMILES
CC1(C)C(CSS(C)(=O)=O)=CC(C)(C)N1[O]
InChi Code
InChI=1S/C10H18NO3S2/c1-9(2)6-8(7-15-16(5,13)14)10(3,4)11(9)12/h6H,7H2,1-5H3
InChi Key
BLSCGBLQCTWVPO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $99

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    10 mg

    $158

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    25 mg

    $371

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    50 mg

    $644

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    Product Description

    MTSSL is a paramagnetic nitroxide spin label featuring a methanethiosulfonate group for site-directed spin labeling, particularly through disulfide linkages with cysteine residues on proteins.1,2 When combined with electron paramagnetic resonance spectroscopy, site-directed spin labeling is used to study the structural dynamics of proteins, including membrane proteins.1,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Perozo, E., Cortes, D.M., and Cuello, L.G. Structural rearrangements underlying K+-channel activation gating. Science 285(5424), 73-78 (1999).

    2. Gaponenko, V., Howarth, J.W., Columbus, L., et al. Protein global fold determination using site-directed spin and isotope labeling. Protein Sci. 9(2), 302-309 (2000).

    3. Tombolato, F., Ferrarini, A., and Freed, J.H. Dynamics of the nitroxide side chain in spin-labeled proteins. J. Phys. Chem. B 110(51), 26248-26259 (2006).