A 5-HT1B and 5-HT1D receptor agonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Rizatriptan (benzoate salt)

Item No. 16475

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine, monobenzoate
CAS Number
145202-66-0
Synonyms
  • MK-462
Molecular Formula
C15H19N5 • C7H6O2
Formula Weight
391.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 20 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
226, 228, 282 nm
SMILES
CN(C)CCC1=CNC2=CC=C(CN3N=CN=C3)C=C21.O=C(O)C4=CC=CC=C4
InChi Code
InChI=1S/C15H19N5.C7H6O2/c1-19(2)6-5-13-8-17-15-4-3-12(7-14(13)15)9-20-11-16-10-18-20;8-7(9)6-4-2-1-3-5-6/h3-4,7-8,10-11,17H,5-6,9H2,1-2H3;1-5H,(H,8,9)
InChi Key
JPRXYLQNJJVCMZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $36

    Add

    10 mg

    $68

    Add

    25 mg

    $135

    Add

    50 mg

    $236

    Add
    Product Description

    Rizatriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (Kis = 4.3 and 10.1 nM, respectively).1 It is selective for 5-HT1B and 5-HT1D receptors over 5-HT1A receptors (Ki = 140 nM). Rizatriptan induces vasoconstriction in isolated human middle meningeal arteries (EC50 = 90 nM).2 In vivo, rizatriptan (50 and 75 mg/kg) reduces head grooming, the number of oculotemporal strokes, eye blinking, and one-eye closures in a Cacna1a mutant transgenic mouse model of migraine.3 Formulations containing rizatriptan have been used in the treatment of migraine.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xu, Y.-C., Schaus, J.M., Walker, C., et al. N-Methyl-5-tert-butyltryptamine: A novel, highly potent 5-HT1D receptor agonist. J. Med. Chem. 42(3), 526-531 (1999).

    2. Longmore, J., Razzaque, Z., Shaw, D., et al. Comparison of the vasoconstrictor effects of rizatriptan and sumatriptan in human isolated cranial arteries: Immunohistological demonstration of the involvement of 5-HT1B-receptors. Br. J. Clin. Pharmacol. 46(6), 577-582 (1998).

    3. Chanda, M.L., Tuttle, A.H., Baran, I., et al. Behavioral evidence for photophobia and stress-related ipsilateral head pain in transgenic Cacna1a mutant mice. Pain 154(8), 1254-1262 (2013).