An α2-adrenergic receptor agonist
Related Products
Analytical Standard(s)
38559Tizanidine (hydrochloride)
Labeled Version(s)
26521Tizanidine-d4 (hydrochloride)
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Tizanidine (hydrochloride)

Item No. 16477

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine, monohydrochloride
CAS Number
64461-82-1
Synonyms
  • DS 103-282
Molecular Formula
C9H8N5ClS • HCl
Formula Weight
290.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 0.2 mg/mlEthanol: 0.2 mg/ml
λmax
228, 319 nm
SMILES
ClC1=C(NC2=NCCN2)C3=NSN=C3C=C1.Cl
InChi Code
InChI=1S/C9H8ClN5S.ClH/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9;/h1-2H,3-4H2,(H2,11,12,13);1H
InChi Key
ZWUKMNZJRDGCTQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

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    Product Description

    Tizanidine is an α2-adrenergic receptor (α2-AR) agonist.1 Administration of tizanidine reduces neuronal excitation induced by noxious stimuli and depresses spontaneous neuronal firing in anesthetized cats. Tizanidine-induced neuronal depression is reversed by the selective α2-AR antagonist RX781094 but not the α1-AR antagonists prazosin (Item No. 15023) and WB-4101. It acts as a muscle relaxant that inhibits α- and γ-rigidity in rats, reflex muscle tone in rabbits, and the linguomandibular reflex in cats without sedative, hemodynamic, or neurochemical effects.2 Formulations containing tizanidine have been used in the treatment of spasticity. This product is also available as an analytical reference standard (Item No. 38559).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Davies, J., and Quinlan, J.E. Selective inhibition of responses of feline dorsal horn neurons to noxious cutaneous stimuli by tizanidine (DS103-282) and noradrenaline: Involvement of α2-adrenoceptors. Neuroscience 16(3), 673-682 (1985).

    2. Sayers, A.C., Bürki, H.R., and Eichenberger, E. The pharmacology of 5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3-benzothiadiazole (DS 103-282), a novel myotonolytic agent. Arzneimittelforschung 30(5), 793-803 (1980).