A non-ionic detergent
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Isomer(s)
26152n-Dodecyl-α-D-maltoside
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n-Dodecyl-β-D-maltoside

Item No. 16494

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
dodecyl 4-O-α-D-glucopyranosyl-β-D-glucopyranoside
CAS Number
69227-93-6
Synonyms
  • DDM
  • Dodecyl Maltoside
Molecular Formula
C24H46O11
Formula Weight
510.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 2 mg/ml
SMILES
OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@](O[C@H]2[C@H](O)[C@@H](O)[C@H](OCCCCCCCCCCCC)O[C@@H]2CO)([H])O1
InChi Code
InChI=1S/C24H46O11/c1-2-3-4-5-6-7-8-9-10-11-12-32-23-21(31)19(29)22(16(14-26)34-23)35-24-20(30)18(28)17(27)15(13-25)33-24/h15-31H,2-14H2,1H3/t15-,16-,17-,18+,19-,20-,21-,22-,23-,24-/m1/s1
InChi Key
NLEBIOOXCVAHBD-QKMCSOCLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $70

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    1 g

    $118

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    5 g

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    Product Description

    n-Dodecyl-β-D-maltoside (DDM) is a non-ionic detergent commonly used to solubilize membrane-associated proteins.1,2 In particular, it helps retain the native conformation and activity of membrane-associated proteins, and facilitates the reforming of these proteins after denaturation.3,4,5 The critical micelle concentration of DDM is approximately 0.18 mM in water, decreases in the presence of sodium chloride or sucrose, and increases in urea.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ellinger, P., Kluth, M., Stindt, J., et al. Detergent screening and purification of the human liver ABC transporters BSEP (ABCB11) and MDR3 (ABCB4) expressed in the yeast Pichia pastoris. PLoS One 8(4), e60620 (2013).

    2. Rouse, S.L., Marcoux, J., Robinson, C.V., et al. Dodecyl maltoside protects membrane proteins in vacuo. Biophys. J. 105(3), 648-656 (2013).

    3. Koch, K.W. Purification and identification of photoreceptor guanylate cyclase. The Journal of Biological Chemisty 266(13), 8634-8637 (1991).

    4. De Foresta, B., Henao, F., and Chameil, P. Cancellation of the cooperativity of Ca2+ binding to sarcoplasmic reticulum Ca2+-ATPase by the non-ionic detergent dodecylmaltoside. Eur. J. Biochem. 223(2), 359-369 (1994).

    5. Zardeneta, G., and Horowitz, P.M. Micelle-assisted protein folding. Denatured rhodanese binding to cardiolipin-containing lauryl maltoside micelles results in slower refolding kinetics but greater enzyme reactivation. The Journal of Biological Chemisty 267(9), 5811-5816 (1992).

    6. Walter, A., Kuehl, G., Barnes, K., et al. The vesicle-to-micelle transition of phosphatidylcholine vesicles induced by nonionic detergents: Effects of sodium chloride, sucrose and urea. Biochim. Biophys. Acta 1508(1-2), 20-33 (2000).