A specific inhibitor of calpains I and II
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Ac-Calpastatin (184-210)

Item No. 16501

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
79079-11-1
Synonyms
  • Calpastatin Peptide B27-WT
Molecular Formula
C142H230N36O44S
Formula Weight
3177.7
Purity
≥98%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CCCCN)NC([C@@H]1CCCN1C([C@@H]2CCCN2C([C@@]([C@H](CC)C)([H])NC([C@@]([C@@H](C)O)([H])NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC(CNC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@@]([C@H](CC)C)([H])NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@H](CO)NC([C@H](CO)NC([C@@H](NC([C@@H]3CCCN3C([C@@H](NC(C)=O)CC(O)=O)=O)=O)CCSC)=O)=O)=O)=O)CC4=CC=C(O)C=C4)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC5=CC=C(O)C=C5)=O)=O)=O)=O)=O)C)=O
InChi Code
InChI=1S/C142H230N36O44S/c1-18-74(11)111(172-129(211)97(65-81-38-42-83(185)43-39-81)168-136(218)113(77(14)181)174-131(213)100(69-180)170-130(212)99(68-179)169-124(206)92(52-60-223-17)162-132(214)101-33-26-57-176(101)138(220)98(66-109(195)196)154-79(16)183)135(217)163-90(46-50-107(191)192)121(203)159-88(44-48-105(187)188)122(204)164-93(61-70(3)4)116(198)152-67-104(186)155-84(29-20-22-53-143)117(199)156-86(31-24-55-150-141(146)147)118(200)160-91(47-51-108(193)194)125(207)171-110(73(9)10)134(216)175-114(78(15)182)137(219)173-112(75(12)19-2)140(222)178-59-28-35-103(178)139(221)177-58-27-34-102(177)133(215)161-85(30-21-23-54-144)120(202)167-96(64-80-36-40-82(184)41-37-80)128(210)157-87(32-25-56-151-142(148)149)119(201)158-89(45-49-106(189)190)123(205)165-95(63-72(7)8)127(209)166-94(62-71(5)6)126(208)153-76(13)115(145)197/h36-43,70-78,84-103,110-114,179-182,184-185H,18-35,44-69,143-144H2,1-17H3,(H2,145,197)(H,152,198)(H,153,208)(H,154,183)(H,155,186)(H,156,199)(H,157,210)(H,158,201)(H,159,203)(H,160,200)(H,161,215)(H,162,214)(H,163,217)(H,164,204)(H,165,205)(H,166,209)(H,167,202)(H,168,218)(H,169,206)(H,170,212)(H,171,207)(H,172,211)(H,173,219)(H,174,213)(H,175,216)(H,187,188)(H,189,190)(H,191,192)(H,193,194)(H,195,196)(H4,146,147,150)(H4,148,149,151)/t74-,75-,76-,77+,78+,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,110-,111-,112-,113-,114-/m0/s1
InChi Key
ZXJCOYBPXOBJMU-HSQGJUDPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    The calpains are a family of calcium-dependent cysteine proteases, with calpain I (µ-calpain) requiring micromolar calcium and calpain II (m-calpain) requiring millimolar calcium.1 Ac-calpastatin (184-210) is an acetylated synthetic peptide from human calpastatin that strongly inhibits both calpains I and II but not papain (a cysteine protease) or trypsin (a serine protease).2 This 27 amino acid peptide is encoded by exon 1B of Ac-calpastatin (184-210) and corresponds to a portion of inhibitory domain 1.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Goll, D.E., Thompson, V.F., Li, H., et al. The calpain system. Physiol. Rev. 83(3), 731-801 (2003).

    2. Maki, M., Bagci, H., Hamaguchi, K., et al. Inhibition of calpain by synthetic oligopeptide corresponding to an exon of the human calpastatin gene. The Journal of Biological Chemisty 264(32), 18866-18869 (1999).

    3. Betts, R., Weinsheimer, S., Blouse, G.E., et al. Structural determinants of the calpain inhibitory activity of calpastatin peptide B27-WT. The Journal of Biological Chemisty 278(10), 7800-7809 (2003).