A selective RORα/RORγ agonist
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SR 1078

Item No. 16503

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4-(trifluoromethyl)-benzamide
CAS Number
1246525-60-9
Molecular Formula
C17H10F9NO2
Formula Weight
431.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 15 mg/mlEthanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
224, 273 nm
SMILES
O=C(NC1=CC=C(C(O)(C(F)(F)F)C(F)(F)F)C=C1)C2=CC=C(C(F)(F)F)C=C2
InChi Code
InChI=1S/C17H10F9NO2/c18-15(19,20)11-3-1-9(2-4-11)13(28)27-12-7-5-10(6-8-12)14(29,16(21,22)23)17(24,25)26/h1-8,29H,(H,27,28)
InChi Key
DUXWIYXHHGNUJU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

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    10 mg

    $169

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    Cayman Chemical
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    Product Description

    SR 1078 is a selective agonist of RORα and RORγ that stimulates ROR transcriptional activity in HEK293 cell reporter assays at concentrations as low as 2 µM without effect at the related liver X receptors and farnesoid X receptors.1 At 5 µM, SR 1078 has been shown to stabilize p53 and to induce apoptosis in HepG2 cancer cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, Y., Kumar, N., Nuhant, P., et al. Identification of a synthetic agonist for the orphan nuclear receptors RORα and RORγ, SR1078. ACS Chem. Biol. 5(11), 1029-1034 (2010).

    2. Wang, Y., Solt, L.A., Kojetin, D.J., et al. Regulation of p53 stability and apoptosis by a ROR agonist. PLoS One 7(4), 1-6 (2012).