Pricing updated 2019-07-18. Prices are subject to change without notice.
2-Oleoyl glycerol (2-OG) is a natural monoacylglycerol with an 18:1 oleoyl group at the sn-2 position of glycerol. 2-OG, like 2-arachidonoyl glycerol (2-AG; Item No. 62160), is metabolized by monoacylglycerol lipase, but, unlike 2-AG, it is not metabolized by cyclooxygenases or lipoxygenases.1,2,3 2-OG is an agonist of GPR119 (EC50 = 2.5 µM), stimulating the release of glucagon-
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Brengdahl, J., and Fowler, C.J. A novel assay for monoacylglycerol hydrolysis suitable for high-
Ghafouri, N., Tiger, G., Razdan, R.K., et al. Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-
3. Woodhams, S.G., Wong, A., Barrett, D.A., et al. Spinal administration of the monoacylglycerol lipase inhibitor JZL184 produces robust inhibitory effects on nociceptive processing and the development of central sensitization in the rat Brit.J.Pharmacol. 167, 1609-1619 (2012).
Hansen, K.B., Rosenkilde, M.M., Knop, F.K., et al. 2-