A metabolite of PGD2
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11β-13,14-dihydro-15-keto Prostaglandin F2α

Item No. 16540

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9α,11β-dihydroxy-15-oxo-prost-5Z-en-1-oic acid
CAS Number
107615-77-0
Synonyms
  • 11β-13,14-dihydro-15-keto PGF2α
  • 11-epi-13,14-dihydro-15-keto PGF2α
Molecular Formula
C20H34O5
Formula Weight
354.5
Purity
≥95%
Formulation (Request formulation change)
A 500 µg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
10 mM Na2CO3: >6.5 mg/ml (from PGF2a)DMF: >100 mg/ml (from PGF2a)DMSO: >100 mg/ml (from PGF2a)Ethanol: >100 mg/ml (from PGF2a)PBS pH 7.2: >10 mg/ml (from PGF2a)
SMILES
O[C@@H]1[C@H](C/C=C\CCCC(O)=O)[C@@H](CCC(CCCCC)=O)[C@@H](O)C1
InChi Code
InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,16-19,22-23H,2-3,5-6,8-14H2,1H3,(H,24,25)/b7-4-/t16-,17-,18+,19+/m1/s1
InChi Key
VKTIONYPMSCHQI-KGILNJEGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    50 µg

    $63

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    100 µg

    $118

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    500 µg

    $481

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    Product Description

    11β-13,14-dihydro-15-keto PGF2α is a metabolite of PGD2 (Item No. 12010) in the 15-hydroxy PGDH pathway.1,2 Infusion or inhalation of tritiated PGD2 in normal males results in the appearance of peak levels of both 11β-PGF2α, as the immediate product, and 11β-13,14-dihydro-15-keto PGF2α in the plasma within 10 minutes.1 Homogenates of human lung metabolize PGD2 first to 11β-PGF2α and then to 11β-15-keto-PGF2α in the presence of NAD+, but not 11β-13,14-dihydro-15-keto PGF2α.2 Guinea pig liver and kidney homogenates metabolize PGD2 to 11β-13,14-dihydro-15-keto PGF2α, via 11β-PGF2α, in the presence of NAD+ and NADP+.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Robinson, C., Hardy, C.C., and Holgate, S.T. The metabolism of prostaglandin D2 after inhalation or intravenous infusion in normal men. Biochim. Biophys. Acta 963(2), 151-161 (1988).

    2. Robinson, C., Herbert, C.A., Bedwell, S., et al. The metabolism of prostaglandin D2. Evidence for the sequential conversion by NADPH and NAD+ dependent pathways. Biochem. Pharmacol. 38(19), 3267-3271 (1989).