A potent, selective inhibitor of farnesyltransferase
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FTase Inhibitor II (trifluoroacetate salt)

Item No. 16607

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[[(2R)-2-amino-3-mercapto-1-oxopropyl]amino]benzoyl]-L-methionine, trifluoroacetate salt
Synonyms
  • Farnesyltransferase Inhibitor II
  • FTI-II
Molecular Formula
C15H21N3O4S2 • XCF3COOH
Formula Weight
371.5
Purity
≥80%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Water: 25 mg/ml
λmax
211, 268 nm
SMILES
O=C(N[C@H](C(O)=O)CCSC)C1=CC=C(NC([C@@H](N)CS)=O)C=C1.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C15H21N3O4S2.C2HF3O2/c1-24-7-6-12(15(21)22)18-13(19)9-2-4-10(5-3-9)17-14(20)11(16)8-23;3-2(4,5)1(6)7/h2-5,11-12,23H,6-8,16H2,1H3,(H,17,20)(H,18,19)(H,21,22);(H,6,7)/t11-,12-;/m0./s1
InChi Key
JZRHODCELOILNW-FXMYHANSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    FTase Inhibitor II is a cell-permeable analog of FPP that potently inhibits FTase (IC50 = 50-75 nM), preventing farnesylation of Ras.1 It does not inhibit geranylgeranyl transferase at similar concentrations (IC50 > 100 µM).1 FTase Inhibitor II displays no toxicity to untransformed cells but blocks Ras-mediated transformation of NIH 3T3 cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Manne, V., Ricca, C.S., Brown, J.G., et al. Ras farnesylation as a target for novel antitumor agents: Potent and selective farnesyl diphosphate analog inhibitors of farnesyltransferase. Drug Dev. Res. 34(2), 121-137 (1995).