An inhibitor of SETD8
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Ryuvidine

Item No. 16614

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione
CAS Number
265312-55-8
Synonyms
  • Cdk4 Inhibitor III
  • Cyclic-dependent Kinase 4 Inhibitor III
  • SPS812
Molecular Formula
C15H12N2O2S
Formula Weight
284.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMF:PBS (pH 7.2) (1:4): 0.2 mg/mlDMSO: 2 mg/mlEthanol: 0.5 mg/ml
λmax
253, 531 nm
SMILES
CC1=CC=C(NC2=CC(C(SC(C)=N3)=C3C2=O)=O)C=C1
InChi Code
InChI=1S/C15H12N2O2S/c1-8-3-5-10(6-4-8)17-11-7-12(18)15-13(14(11)19)16-9(2)20-15/h3-7,17H,1-2H3
InChi Key
HFPLHASLIOXVGS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $37

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    5 mg

    $106

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    10 mg

    $176

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    25 mg

    $349

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    Product Description

    Ryuvidine is an inhibitor of SETD8 (IC50 = 0.5 µM) that suppresses monomethylation of H4K20 in vitro.1 It less potently inhibits cyclin-dependent kinase 4 (Cdk4; IC50 = 6 µM for Cdk4/cyclin D1).2 Over several hours of treatment, ryuvidine suppresses the expression of cell division cycle 7-related kinase (Cdc7), resulting in an ATM-dependent checkpoint response and arrest of cell cycling in S phase.1,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Blum, G., Ibáñez, G., Rao, X., et al. Small-molecule inhibitors of SETD8 with cellular activity. ACS Chem. Biol. 9(11), 2471-2478 (2014).

    2. Ryu, C.K., Kang, H.Y., Lee, S.K., et al. 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents. Bioorg. Med. Chem. Lett. 10, 461-464 (2000).

    3. FitzGerald, J., Murillo, L.S., O'Brien, G., et al. A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response. PLoS One 9(6), (2014).