A mitochondria-targeted antioxidant
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MitoTEMPO (hydrate)

Item No. 16621

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,2,6,6-tetramethyl-4-[[2-(triphenylphosphonio)acetyl]amino]-1-piperidinyloxy, monochloride, monohydrate
CAS Number
1569257-94-8
Molecular Formula
C29H35N2O2P • Cl [H2O]
Formula Weight
528.0
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 10 mg/mlEthanol: 15 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
225, 268 nm
SMILES
O=C(NC1CC(C)(C)N([O])C(C)(C)C1)C[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4.[Cl-].O
InChi Code
InChI=1S/C29H34N2O2P.ClH.H2O/c1-28(2)20-23(21-29(3,4)31(28)33)30-27(32)22-34(24-14-8-5-9-15-24,25-16-10-6-11-17-25)26-18-12-7-13-19-26;;/h5-19,23H,20-22H2,1-4H3;1H;1H2
InChi Key
AIAJCDXYZBOVGT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $65

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    10 mg

    $104

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    25 mg

    $244

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    50 mg

    $390

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    Product Description

    MitoTEMPO is a mitochondria-targeted superoxide dismutase mimetic that possesses superoxide and alkyl radical scavenging properties.1 This compound combines the antioxidant piperidine nitroxide TEMPO with the lipophilic cation triphenylphosphonium, which allows it to pass through lipid bilayers and accumulate in mitochondria.1 Mitochondrial targeting of superoxide scavenging via mitoTEMPO has been examined for potential therapeutic benefit to a variety of mitochondrial dysfunctions arising from excessive reactive oxygen species.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dikalov, S. Cross talk between mitochondria and NADPH oxidases. Free Radic. Biol. Med. 51(7), 1289-1301 (2011).

    2. Liang, H.L., Arsenault, J., Mortensen, J., et al. Partial attenuation of cytotoxicity and apoptosis by SOD1 in ischemic renal epithelial cells. Apoptosis 14(10), 1176-1189 (2009).

    3. Dikalova, A.E., Bikineyeva, A.T., Budzyn, K., et al. Therapeutic targeting of mitochondrial superoxide in hypertension. Circ. Res. 107(1), 106-116 (2010).

    4. Liang, H.L., Sedlic, F., Bosnjak, Z., et al. SOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis, and mitochondrial apoptosis after ATP depletion recovery. Free Radic. Biol. Med. 49(10), 1550-1560 (2010).

    Product Citations

    Ting, K.K.Y., Ibrahim, H.M., Gulati, N., et al. Intracellular accumulation of free cholesterol in macrophages triggers a PARP1 response to DNA damage and PARP1 impairs lipopolysaccharide-induced inflammatory response. PLoS One 20(3), e0318267 (2025).

    Wang, X., Shelton, S.D., Bordieanu, B., et al. Scinderin promotes fusion of electron transport chain dysfunctional muscle stem cells with myofibers. Nat. Aging 2(2), s43587-43021-00164-x. (2024).

    Skytthe, M.K., Graversen, J.H., and Moestrup, S.K. Targeting of CD163+ macrophages in inflammatory and malignant diseases. Int. J. Mol. Sci. 21(15), 5497 (2020).