An antimetabolite for the tryptophan pathway
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Product Type

Biochemicals

Research Area

2-Amino-5-fluorobenzoic Acid

Item No. 16669

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-5-fluoro-benzoic acid
CAS Number
446-08-2
Synonyms
  • 5-FAA
  • 5-Fluoroanthranilic Acid
  • NSC 513308
Molecular Formula
C7H6FNO2
Formula Weight
155.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 0.25 mg/ml
λmax
215, 245, 348 nm
SMILES
NC1=C(C(O)=O)C=C(F)C=C1
InChi Code
InChI=1S/C7H6FNO2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,9H2,(H,10,11)
InChi Key
FPQMGQZTBWIHDN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $54

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    5 g

    $209

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    10 g

    $392

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    Product Description

    2-Amino-5-fluorobenzoic acid is a toxic antimetabolite for the tryptophan pathway in yeast that can be used to counterselect for TRP1, a commonly used genetic marker in S. cerevisiae.1 Because this trp1 strain lacks the enzymes required for the conversion of anthranilic acid to tryptophan, it is resistant to 2-amino-5-fluorobenzoic acid feedback inhibition, enabling a growth-based, positive selection of the TRP1 marker. 2-Amino-5-fluorobenzoic acid is frequently used in genetic procedures that involve plasmid manipulations.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Toyn, J.H., Gunyuzlu, P.L., White, W.H., et al. A counterselection for the tryptophan pathway in yeast: 5-Fluoroanthranilic acid resistance. Yeast 16(6), 553-560 (2000).