P7C3

P7C3 is an orally bioavailable and brain penetrant aminopropyl carbazole that exhibits proneurogenic and neuroprotective activity by preventing apoptosis of newly postmitotic neurons in the subgranular zone of the hippocampal dentate gyrus.¹ At doses of 5 mg/kg and above, it has been shown to promote the survival of neurons in various rodent models of neurodegeneration or nerve injury.^2,3 While the precise mechanism of action through which these effects are exerted remains uncertain, P7C3 recently has been shown to bind nicotinamide phosphoribosyltransferase, the rate-limiting enzyme involved in the conversion of nicotinamide into NAD.⁴

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1. Pieper, A.A., Xie, S., Capota, E., et al. Discovery of a pro-neurogenic, neuroprotective chemical. Cell 142(1), 39-51 (2010).

2. De Jesús-Cortés, H., Xu, P., Drawbridge, J., et al. Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease. Proc. Natl. Acad. Sci. USA 109(42), 17010-17015 (2012).

3. Tesla, R., Wolf, H.P., Xu, P., et al. Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. USA 109(42), 17016-17021 (2012).

4. Wang, G., Han, T., Nijhawan, D., et al. P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage. Cell 158(6), 1324-1334 (2014).