A nucleophosmin inhibitor
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Product Categories

Product Type

Biochemicals

Research Area

Cancer
Cell Death
Apoptosis

NSC 348884

Item No. 16716

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N1,N1,N2,N2-tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]-1,2-ethanediamine
CAS Number
81624-55-7
Molecular Formula
C38H40N10
Formula Weight
636.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS(pH7.2) (1:2): 0.25 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/ml
λmax
247, 281, 287 nm
SMILES
CC(C=C1)=CC2=C1NC(CN(CC3=NC(C=CC(C)=C4)=C4N3)CCN(CC5=NC6=C(C=C(C)C=C6)N5)CC7=NC(C=CC(C)=C8)=C8N7)=N2
InChi Code
InChI=1S/C38H40N10/c1-23-5-9-27-31(15-23)43-35(39-27)19-47(20-36-40-28-10-6-24(2)16-32(28)44-36)13-14-48(21-37-41-29-11-7-25(3)17-33(29)45-37)22-38-42-30-12-8-26(4)18-34(30)46-38/h5-12,15-18H,13-14,19-22H2,1-4H3,(H,39,43)(H,40,44)(H,41,45)(H,42,46)
InChi Key
KZOLQEUQAFTQFM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $130

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    10 mg

    $236

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    25 mg

    $527

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    Product Description

    Nucleophosmin is a nucleolar phosphoprotein involved in cell proliferation, cytoplasmic/nuclear shuttle transportation, nucleic acid binding, ribonucleic cleavage, centrosome duplication, and molecular chaperoning. Its activity is dependent on oligomerization at its N-terminal domain, and it is abundantly expressed in tumor and developing cells where it serves to inhibit both cellular differentiation and apoptosis.1 NSC 348884 is a small molecule that inhibits the formation of nucleophosmin dimers by disrupting a required binding pocket. It can inhibit cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 µM.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Qi, W., Shakalya, K., Stejskal, A., et al. NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancer cells. Oncogene 27(30), 4210-4220 (2008).

    2. Zhang, J., Zhao, H.L., He, J.f., et al. Inhibitory effect of NSC348884, a small molecular inhibitor of nucleophosmin, on the growth of hepatocellular carcinoma cell line hepG2. Zhongguo Yi Xue Ke Yuan Xue Bao 34(1), 58-61 (2012).