A carbonic anhydrase inhibitor
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U-104

Item No. 16717

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[[(4-fluorophenyl)amino]carbonyl]amino]-benzenesulfonamide
CAS Number
178606-66-1
Synonyms
  • NSC 213841
Molecular Formula
C13H12FN3O3S
Formula Weight
309.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 2 mg/ml
λmax
270 nm
SMILES
FC1=CC=C(NC(NC2=CC=C(S(N)(=O)=O)C=C2)=O)C=C1
InChi Code
InChI=1S/C13H12FN3O3S/c14-9-1-3-10(4-2-9)16-13(18)17-11-5-7-12(8-6-11)21(15,19)20/h1-8H,(H2,15,19,20)(H2,16,17,18)
InChi Key
YJQZNWPYLCNRLP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $53

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    10 mg

    $98

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    25 mg

    $194

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    50 mg

    $357

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    Cayman Chemical
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    Product Description

    U-104 is a ureido-sulfonamide inhibitor of transmembrane CAIX (Ki = 45.1 nM) and CAXII (Ki = 4.5 nM).1 It demonstrates reduced affinity for the cytosolic isoforms, CAI and CAII (Kis = 5.08 and 9.64 µM, respectively).1 U-104 associates with CAIX/CAXII only under hypoxic conditions in vivo, reducing extracellular acidity and resulting in significant inhibition of tumor growth and metastasis in experimental models.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lou, Y., McDonald, P.C., Oloumi, A., et al. Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Res. 71(9), 3364-3376 (2011).