A potent NK3 receptor agonist
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Senktide (trifluoroacetate salt)

Item No. 16721

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(3-carboxy-1-oxopropyl)-L-α-aspartyl-L-phenylalanyl-N-methyl-L-phenylalanylglycyl-L-leucyl-L-methioninamide, trifluoroacetate salt
Molecular Formula
C40H55N7O11S • XCF3COOH
Formula Weight
842.0
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 5 mg/mlPBS (pH 7.2): 2 mg/ml
SMILES
CN(C([C@@H](NC([C@@H](NC(CCC(O)=O)=O)CC(O)=O)=O)CC1=CC=CC=C1)=O)[C@H](C(NCC(N[C@H](C(N[C@@H](CCSC)C(N)=O)=O)CC(C)C)=O)=O)CC2=CC=CC=C2.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C40H55N7O11S.C2HF3O2/c1-24(2)19-28(37(55)45-27(36(41)54)17-18-59-4)44-33(49)23-42-39(57)31(21-26-13-9-6-10-14-26)47(3)40(58)30(20-25-11-7-5-8-12-25)46-38(56)29(22-35(52)53)43-32(48)15-16-34(50)51;3-2(4,5)1(6)7/h5-14,24,27-31H,15-23H2,1-4H3,(H2,41,54)(H,42,57)(H,43,48)(H,44,49)(H,45,55)(H,46,56)(H,50,51)(H,52,53);(H,6,7)/t27-,28-,29-,30-,31-;/m0./s1
InChi Key
VDAQXEICYJWWRA-FIYBGCGXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $90

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    1 mg

    $158

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    5 mg

    $653

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    Product Description

    Senktide is a potent, selective agonist of the neuromedin K3 (NK3) receptor (EC50 = 0.5-3 nM).1,2,3 It less potently agonizes the NK1 receptor (EC50 = 35 µM) and is without effect on the NK2 receptor.1,2,3 Senktide is used to study the action of the NK3 receptor in cells and in animals.4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Byk, G., Halle, D., Zeltser, I., et al. Synthesis and biological activity of NK-1 selective, N-backbone cyclic analogs of the C-terminal hexapeptide of substance P. J. Med. Chem 39(16), 3174-3178 (1996).

    2. Sarau, H.M., Griswold, D.E., Potts, W., et al. Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist. J. Pharmacol. Exp. Ther. 281(3), 1303-1311 (1997).

    3. Harrison, T., Korsgaard, M.P., Swain, C.J., et al. High affinity, selective neurokinin 2 and neurokinin 3 receptor antagonists from a common structural template. Bioorg. Med. Chem. Lett. 8(11), 1343-1348 (1998).

    4. Thakar, A., Sylar, E., and Flynn, F.W. Activation of tachykinin, neurokinin 3 receptors affects chromatin structure and gene expression by means of histone acetylation. Peptides 38(2), 282-290 (2012).

    5. Gaskins, G.T., Glanowska, K.M., and Moenter, S.M. Activation of neurokinin 3 receptors stimulates GnRH release in a location-dependent but kisspeptin-independent manner in adult mice. Endocrinology 154(11), 3984-3989 (2013).