A metabolically stable PGF2α analog that acts as a luteolytic agent
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15(S)-15-methyl Prostaglandin F2α

Item No. 16743

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9α,11α,15S-trihydroxy-15-methyl-prosta-5Z,13E-dien-1-oic acid
CAS Number
35700-23-3
Synonyms
  • Carboprost
  • 15(S)-15-methyl PGF2α
  • U-32921
Molecular Formula
C21H36O5
Formula Weight
368.5
Purity
≥98%
Formulation (Request formulation change)
A 5 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
10 mM Na2CO3: >6.5 mg/mlDMF: >100 mg/mlDMSO: >100 mg/mlEthanol: >100 mg/mlPBS (pH 7.2): >10 mg/ml
SMILES
O[C@@H]1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@](O)(C)CCCCC)[C@H](O)C1
InChi Code
InChI=1S/C21H36O5/c1-3-4-9-13-21(2,26)14-12-17-16(18(22)15-19(17)23)10-7-5-6-8-11-20(24)25/h5,7,12,14,16-19,22-23,26H,3-4,6,8-11,13,15H2,1-2H3,(H,24,25)/b7-5-,14-12+/t16-,17-,18+,19-,21+/m1/s1
InChi Key
DLJKPYFALUEJCK-IIELGFQLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Product Description

    15(S)-15-methyl Prostaglandin F2α (15(S)-15-methyl PGF2α) is a metabolically stable analog of PGF2α. It is a potent uterine stimulant and abortifacient which can be administered intramuscularly to induce labor.1,2,3 It induces luteolysis and reduces serum progesterone concentrations when given as an intramuscular injection in non-pregnant rhesus monkeys.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Carlan, S.J., Gushwa, J.P., O'Brien, W.F., et al. Effect of intramuscular 15-methyl prostaglandin F2α after second-trimester delivery. Obstet. Gynecol. 89(1), 5-9 (1997).

    2. Lindblom, B., Källfelt, B., Hahlin, M., et al. Local prostaglandin F2α injection for termination of ectopic pregnancy. Lancet 1(8536), 776-777 (1987).

    3. Adaikan, P.G., Prasad, R.N.V., Kottegoda, S.R., et al. Effect of indomethacin on the injection-abortion interval of 15(S)15 methyl PGF2α-induced mid-trimester abortions - a randomized study. Prostaglandins Leukot. Med. 27(2-3), 161-167 (1987).

    4. Wilks, J.W. Inhibition of the monkey corpus luteum with 15-methyl prostaglandins. Prostaglandins 20(5), 793-805 (1980).