Cloprostenol (sodium salt)

Item № 16764
CAS № 55028-72-3
Purity ≥98%
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL $0.00
1 mg $37.00 0.00
5 mg $167.00 0.00
10 mg $241.00 0.00

Pricing updated 2018-02-18. Prices are subject to change without notice.

Description
Synonyms
  • (±)-16-m-chlorophenoxy tetranor PGF
  • (±)-16-m-chlorophenoxy tetranor Prostaglandin F
  • DL-Cloprostenol

Cloprostenol (sodium salt) is a more water solute, crystalline form of cloprostenol than the free acid. Cloprostenol is a synthetic analog of prostaglandin F (PGF). It is 200 times and 100 times more potent than PGF in terminating pregnancy in hamsters and rats, respectively, without the side effects associated with PGF.1 The subcutaneous dose required for interrupting early pregnancy is species dependent, requiring approximately 1.25 µg/kg and 270 µg/kg in hamsters and rats, respectively.1 Cloprostenol is also a potent inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 of 3 x 10−12 M.2

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Technical Information
Formal Name
(±)-9α,11α,15R-trihydroxy-16-(3-chlorophenoxy)-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic acid, sodium salt
CAS Number
55028-72-3
Synonyms
  • (±)-16-m-chlorophenoxy tetranor PGF
  • (±)-16-m-chlorophenoxy tetranor Prostaglandin F
  • DL-Cloprostenol
Molecular Formula
C22H28ClO6 • Na
Formula Weight
446.9
Purity
≥98%
Formulation
A crystalline solid
λmax
275, 282 nm
SMILES
O[C@@H]1[C@H](C/C=C\CCCC([O-])=O)[C@@H](/C=C/[C@@H](O)COC2=CC=CC(Cl)=C2)[C@H](O)C1.[Na+]
InChI Code
InChI=1S/C22H29ClO6.Na/c23-15-6-5-7-17(12-15)29-14-16(24)10-11-19-18(20(25)13-21(19)26)8-3-1-2-4-9-22(27)28;/h1,3,5-7,10-12,16,18-21,24-26H,2,4,8-9,13-14H2,(H,27,28);/q;+1/p-1/b3-1-,11-10+;/t16-,18-,19-,20+,21-;/m1./s1
InChI Key
IFEJLMHZNQJGQU-KXXGZHCCSA-M

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Dukes, M.,Russell, W., and Walpole, A.L. Potent luteolytic agents related to prostaglandin F. Nature 250, 330-331 (1974).

2. Serrero, G., and Lepak, N.M. Prostaglandin F receptor (FP receptor) agonists are potent adipose differentiation inhibitors for primary culture of adipocyte precursors in defined medium. Biochemical and Biophysical Research Communications 233, 200-202 (1997).

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