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(+)-Cloprostenol

Item № 16765
CAS № 54276-21-0
Purity ≥97%
product image
                (CAS 54276-21-0)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $58.00 0.00
     5 mg $261.00 0.00
     10 mg $464.00 0.00

Pricing updated 2019-07-18. Prices are subject to change without notice.

Description
Synonyms
  • D-Cloprostenol
  • (+)-16-m-chlorophenoxy tetranor PGF
  • (+)-16-m-chlorophenoxy tetranor Prostaglandin F

(+)-Cloprostenol is a synthetic analog of prostaglandin F (PGF). It is an FP receptor agonist and a potent luteolytic agent in rats and hamsters. (+)-Cloprostenol is the optically active, 15(R) enantiomer of cloprostenol responsible for the majority of its biological activity. It is 200 times more potent than PGF in terminating pregnancy when given subcutaneously at a daily dose of 0.125 μg/kg in rats and hamsters, without the side effects associated with PGF.1 (+)-Cloprostenol was also shown to be a potent inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 value of 3 pM.2

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Technical Information
Formal Name
(+)-9α,11α,15R-trihydroxy-16-(3-chlorophenoxy)-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic acid
CAS Number
54276-21-0
Synonyms
  • D-Cloprostenol
  • (+)-16-m-chlorophenoxy tetranor PGF
  • (+)-16-m-chlorophenoxy tetranor Prostaglandin F
Molecular Formula
C22H29ClO6
Formula Weight
424.9
Purity
≥97%
Formulation
A solution in ethanol
λmax
220, 275, 282 nm
SMILES
O[C@@H]1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)COC2=CC=CC(Cl)=C2)[C@H](O)C1
InChI Code
InChI=1S/C22H29ClO6/c23-15-6-5-7-17(12-15)29-14-16(24)10-11-19-18(20(25)13-21(19)26)8-3-1-2-4-9-22(27)28/h1,3,5-7,10-12,16,18-21,24-26H,2,4,8-9,13-14H2,(H,27,28)/b3-1-,11-10+/t16-,18-,19-,20+,21-/m1/s1
InChI Key
VJGGHXVGBSZVMZ-QIZQQNKQSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Dukes, M., Russell, W., and Walpole, A.L. Potent luteolytic agents related to prostaglandin F Nature 250(464), 330-331 (1974).

2. Serrero, G., and Lepak, N.M. Prostaglandin F receptor (FP receptor) agonists are potent adipose differentiation inhibitors for primary culture of adipocyte precursors in defined medium Biochemical and Biophysical Research Communications 233(1), 200-202 (1997).

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