(+)-Cloprostenol (sodium salt)
Item № 16766
CAS № 62561-03-9
Purity ≥98%
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1 mg $49.00 $0.00
5 mg $221.00 $0.00
10 mg $392.00 $0.00

Pricing updated 2016-05-26. Prices are subject to change without notice.

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Description
Synonyms
  • D-Cloprostenol
  • (+)-16-m-chlorophenoxy tetranor PGF
  • (+)-16-m-chlorophenoxy tetranor Prostaglandin F

(+)-Cloprostenol (sodium salt) is a more water soluble, crystalline form of (+)-cloprostenol. (+)-Cloprostenol is a synthetic analog of prostaglandin F (PGF). It is an FP receptor agonist and a potent luteolytic agent in rats and hamsters. (+)-Cloprostenol is the optically active, 15(R) enantiomer of cloprostenol responsible for the majority of its biological activity. Cloprostenol is 200 times and 100 times more potent than PGF in terminating pregnancy in hamsters and rats, respectively without the side effects associated with PGF.1 The subcutaneous dose required for interrupting early pregnancy is species dependent, requiring approximately 1.25 µg/kg and 270 µg/kg in hamsters and rats, respectively.1 Cloprostenol is also a potent inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 of 3 x 10−12 M.2

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Technical Information
Formal Name (+)-9α,11α,15R-trihydroxy-16-(3-chlorophenoxy)-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic acid, sodium salt
CAS Number 62561-03-9
Synonyms
  • D-Cloprostenol
  • (+)-16-m-chlorophenoxy tetranor PGF
  • (+)-16-m-chlorophenoxy tetranor Prostaglandin F
Molecular Formula C22H28ClO6 • Na
Formula Weight 446.9
Purity ≥98%
Formulation A crystalline solid
λmax 275, 282 nm
SMILES O[C@@H]1[C@H](C/C=C\CCCC([O-])=O)[C@@H](/C=C/[C@@H](O)COC2=CC=CC(Cl)=C2)[C@H](O)C1.[Na+]
InChI Code 1S/C22H29ClO6.Na/c23-15-6-5-7-17(12-15)29-14-16(24)10-11-19-18(20(25)13-21(19)26)8-3-1-2-4-9-22(27)28;/h1,3,5-7,10-12,16,18-21,24-26H,2,4,8-9,13-14H2,(H,27,28);/q;+1/p-1/b3-1-,11-10+;/t16-,18-,19-,20+,21-;/m1./s1
InChI Key IFEJLMHZNQJGQU-KXXGZHCCSA-M

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Stability As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
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Additional Information

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References & Background Reading
Product Description References

1. Dukes, M., Russell, W., and Walpole, A.L. Potent luteolytic agents related to prostaglandin F2.alpha.. Nature 250 330-331 (1974).

2. Serrero, G., and Lepak, N.M. Prostaglandin F2.alpha. receptor (FP receptor) agonists are potent adipose differentiation inhibitors for primary culture of adipocyte precursors in defined medium. Biochem Biophys Res Commun 233 200-202 (1997).

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