Binds CBFβ and disrupts CBF function
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

CBFβ Inhibitor

Item No. 16771

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-ethyl-4-(4-methoxyphenyl)-2-thiazolamine
CAS Number
493028-20-9
Synonyms
  • Core Binding Factor-β Inhibitor
Molecular Formula
C12H14N2OS
Formula Weight
234.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 30 mg/mlEthanol: 25 mg/ml
λmax
239 nm
SMILES
COC1=CC=C(C2=C(CC)SC(N)=N2)C=C1
InChi Code
InChI=1S/C12H14N2OS/c1-3-10-11(14-12(13)16-10)8-4-6-9(15-2)7-5-8/h4-7H,3H2,1-2H3,(H2,13,14)
InChi Key
QHRCVGXBBIRPTE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $80

    Add

    10 mg

    $149

    Add

    25 mg

    $332

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ.1 CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias.1,2 CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 µM).3 It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Link, K.A., Chou, F.S., and Mulloy, J.C. Core binding factor at the crossroads: Determining the fate of the HSC. J. Cell. Physiol. 222(1), 50-56 (2010).

    2. Swiers, G., de Bruijn, N., and Speck, N.A. Hematopoietic stem cell emergence in the conceptus and the role of Runx1. Int. J. Dev. Biol. 54(6-7), 1151-1163 (2010).

    3. Gorczynski, M.J., Grembecka, J., Zhou, Y., et al. Allosteric inhibition of the protein-protein interaction between the leukemia-associated proteins Runx1 and CBFβ. Chem. Biol. 14(10), 1186-1197 (2007).