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D-Glucose, a naturally occurring monosaccharide found in plants, is the primary energy source for living organisms.1 It is utilized as a metabolic intermediate by cells for either aerobic or anaerobic respiration. D-Glucose exists in two cyclic forms, α-D-glucose and β-D-glucose, based on the position of the substituent at the anomeric center.2 α-D-Glucose is the monomer unit in starch, whereas β-D-glucose is the monomer unit in cellulose.2 When one of these anomers is added to solution, it undergoes reversible epimerization to the other via an open-chain form, during which the specific rotation of the solution changes gradually until it reaches equilibrium. The existence of multiple binding modes of this single monosaccharide has been studied as a model scaffold to design compounds with increased probability of ligand binding.3
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1. D-
2. Carbohydrates. Principles of biochemistry 9, 16-22 (1993).
3. The β-