A negative control for PMA
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4α-Phorbol 12-myristate 13-acetate

Item No. 16806

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
tetradecanoic acid, (4aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1aR,1bS,4,4a,5,7aS,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl ester
CAS Number
63597-44-4
Synonyms
  • 4α-PMA
Molecular Formula
C36H56O8
Formula Weight
616.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleEthanol: Soluble
SMILES
OCC1=C[C@]2([H])[C@]([C@@](C=C(C)C3=O)([H])[C@@]3(O)C1)(O)[C@H](C)[C@@H](OC(CCCCCCCCCCCCC)=O)[C@]4(OC(C)=O)[C@H]2C4(C)C
InChi Code
InChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34+,35-,36-/m1/s1
InChi Key
PHEDXBVPIONUQT-LQLWEASQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    4α-PMA is a structural analog of PMA that does not activate PKC.1,2 It is used as a negative control for PMA signaling through PKC.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fischer, S.M., Patrick, K.E., Lee, M.L., et al. 4β- and 4α-12-O-tetradecanoylphorbol-13-acetate elicit arachidonate release from epidermal cells through different mechanisms. Cancer Res. 51(3), 850-856 (1991).

    2. Savage, M.J., Trusko, S.P., Howland, D.S., et al. Turnover of amyloid β-protein in mouse brain and acute reduction of its level by phorbol ester. J. Neurosci. 18(5), 1743-1752 (1998).