A derivative of latanoprost and an analytical standard
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5-trans Latanoprost

Item No. 16813

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5E)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-5-heptenoic acid, 1-methylethyl ester
CAS Number
913258-34-1
Synonyms
  • 5,6-trans Latanoprost
Molecular Formula
C26H40O5
Formula Weight
432.6
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 100 mg/mlDMSO: 50 mg/mlEthanol: MisciblePBS (pH 7.2): 1.5 mg/ml
SMILES
O[C@@H]1[C@H](C/C=C/CCCC(OC(C)C)=O)[C@@H](CC[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C1
InChi Code
InChI=1S/C26H40O5/c1-19(2)31-26(30)13-9-4-3-8-12-22-23(25(29)18-24(22)28)17-16-21(27)15-14-20-10-6-5-7-11-20/h3,5-8,10-11,19,21-25,27-29H,4,9,12-18H2,1-2H3/b8-3+/t21-,22+,23+,24-,25+/m0/s1
InChi Key
GGXICVAJURFBLW-RDSJPUOVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $660

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    50 mg

    $2,063

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    Product Description

    5-trans Latanoprost is a derivative of the FP receptor agonist latanoprost (free acid) (Item No. 16811) and the trans isomer of latanoprost (Item No. 16812).1 Like other trans isomers of F-type prostaglandins, 5-trans latanoprost may have similar FP receptor activation and intraocular pressure reduction activities as the cis isomer. 5-trans Latanoprost is a potential impurity in commercial preparations of latanoprost. This product is intended as an analytical standard for the detection and quantification of this impurity.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Asendrych-Wicik, K., Zarczuk, J., Walaszek, K., et al. Trends in development and quality assessment of pharmaceutical formulations - F2α analogues in the glaucoma treatment. Eur. J. Pharm. Sci. 180, 106315 (2023).