A 15(R) isomer of 17-phenyl trinor PGF2α and active metabolite of 17-phenyl trinor PGF2α ethyl amide
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15(R)-17-phenyl trinor Prostaglandin F2α

Item No. 16814

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9α,11α,15R-trihydroxy-17-phenyl-18,19,20-trinor-prosta-5Z,13E-dien-1-oic acid
CAS Number
41639-71-8
Synonyms
  • 15-epi Bimatoprost (free acid)
  • 15(R)-Bimatoprost (free acid)
  • 15(R)-17-phenyl trinor PGF2α
Molecular Formula
C23H32O5
Formula Weight
388.5
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 25 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
O[C@@H]1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@H](O)CCC2=CC=CC=C2)[C@H](O)C1
InChi Code
InChI=1S/C23H32O5/c24-18(13-12-17-8-4-3-5-9-17)14-15-20-19(21(25)16-22(20)26)10-6-1-2-7-11-23(27)28/h1,3-6,8-9,14-15,18-22,24-26H,2,7,10-13,16H2,(H,27,28)/b6-1-,15-14+/t18-,19-,20-,21+,22-/m1/s1
InChi Key
YFHHIZGZVLHBQZ-MTDOSWCTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    15(R)-17-phenyl trinor Prostaglandin F2α (15(R)-17-phenyl trinor PGF2α) is the 15(R) isomer of the FP receptor agonist 17-phenyl trinor PGF2α (Item No. 16810). 17-phenyl trinor PGF2α is an active metabolite of the prodrug 17-phenyl trinor PGF2α ethyl amide (Item No. 16820).1 It is formed from 17-phenyl trinor PGF2α ethyl amide by amidases. 15(R)-17-phenyl trinor PGF2α is a potential agonist of the FP receptor. It induces relaxation of isolated cat iris sphincter muscles (EC50 = 30 nM).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Maxey, K.M., Johnson, J., and LaBrecque, J. The hydrolysis of bimatoprost in corneal tissue generates a potent prostanoid FP receptor agonist. Surv. Ophthalmol. 47(Suppl. 1), S34-S40 (2002).

    2. Resul, B., Stjernschantz, J., No, K., et al. Phenyl-substituted prostaglandins: Potent and selective antiglaucoma agents. J. Med. Chem. 36(2), 243-248 (1993).