Inhibitor of indoleamine 2,3-dioxygenase
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Product Type

Small Molecule Modulators
Small Molecule Inhibitors

Research Area

CAY10581

Item No. 16838

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(±)3,4-dihydro-3-hydroxy-2,2-dimethyl-4-[(phenylmethyl)amino]-2H-naphtho[2,3-b]pyran-5,10-dione
CAS Number
1018340-07-2
Molecular Formula
C22H21NO4
Formula Weight
363.4
Purity
≥97%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7.2) (1:9): 0.1 mg/mlDMSO: 3 mg/ml
λmax
252, 279, 334 nm
SMILES
O=C1C2=C([C@H](NCC3=CC=CC=C3)[C@H](O)C(C)(C)O2)C(C4=C1C=CC=C4)=O
InChi Code
InChI=1S/C22H21NO4/c1-22(2)21(26)17(23-12-13-8-4-3-5-9-13)16-18(24)14-10-6-7-11-15(14)19(25)20(16)27-22/h3-11,17,21,23,26H,12H2,1-2H3/t17-,21-/m0/s1
InChi Key
WKHJQIQDQXGUOD-UWJYYQICSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $178

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    10 mg

    $312

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    25 mg

    $680

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    Product Description

    CAY10581 acts as a reversible uncompetitive inhibitor of IDO and demonstrates minimal impact on cell viability at 100 μM after 24 hours.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kumar, S., Malachowski, W.P., DuHadaway, J.B., et al. Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. J. Med. Chem. 51(6), 1706-1718 (2008).

    Product Citations

    Moyer, B.J., Rojas, I.Y., Murray, I.A., et al. Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors activate the aryl hydrocarbon receptor. Toxicol. Appl. Pharmacol. 323, 74-80 (2017).