Pricing updated 2019-07-18. Prices are subject to change without notice.
CFI-400945 is an orally available, selective inhibitor of polo-like kinase 4 (PLK4; IC50 = 2.8 nM), a unique kinase that regulates centriole duplication during the cell cycle.1 It does not inhibit other members of the PLK family (IC50s > 50 µM for PLK1, PLK2, and PLK3).1 CFI-400945 has been shown to dysregulate centriole duplication, disrupt mitosis, and induce apoptosis in various PLK4-overexpressing breast cancer cells and to reduce tumor growth in mice bearing MDA-MB-468 breast tumor xenografts.1
Warning - this product is not for human or veterinary use.
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Mason, J.M., Lin, D.C., Wei, X., et al. Functional characterization of CFI-