An activator of phospholipase C
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m-3M3FBS

Item No. 16867

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]-benzenesulfonamide
CAS Number
200933-14-8
Molecular Formula
C16H16F3NO2S
Formula Weight
343.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
230 nm
SMILES
O=S(NC1=CC(C(F)(F)F)=CC=C1)(C2=C(C)C=C(C)C=C2C)=O
InChi Code
InChI=1S/C16H16F3NO2S/c1-10-7-11(2)15(12(3)8-10)23(21,22)20-14-6-4-5-13(9-14)16(17,18)19/h4-9,20H,1-3H3
InChi Key
ZIIUUSVHCHPIQD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $54

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    10 mg

    $102

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    25 mg

    $223

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    50 mg

    $418

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    Product Description

    m-3M3FBS is an activator of phospholipase C (PLC) that stimulates superoxide generation, increase in cytoplasmic calcium, and inositol phosphate formation in human neutrophils when used at a concentration of 15-50 µM.1 It stimulates cytoplasmic calcium increases in several cell lines and, at 25 µM in vitro, promotes the hydrolysis of phosphatidylinositol bisphosphate by all PLC isoforms.1 m-3M3FBS is used to study PLC signaling in cells and animals, often in conjunction with the PLC inhibitor U-73122 (Item No. 70740).2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bae, Y.S., Lee, T.G., Park, J.C., et al. Identification of a compound that directly stimulates phospholipase C activity. Mol. Pharmacol. 63(5), 1043-1050 (2003).

    2. Kim, S.D., Kim, H.J., Shim, J.W., et al. Phospholipase C activator m-3M3FBS protects against morbidity and mortality associated with sepsis. J. Immunol. 189(4), 2000-2005 (2012).

    3. Semple-Rowland, S., Madorsky, I., Bolch, S., et al. Activation of phospholipase C mimics the phase shifting effects of light on melatonin rhythms in retinal photoreceptors. PLoS One 8(12), e83378 (2013).

    4. Szebenyi, S.A., Ogura, T., Sathyanesan, A., et al. Increases in intracellular calcium via activation of potentially multiple phospholipase C isozymes in mouse olfactory neurons. Front. Cell. Neurosci. 8, 336 (2014).