A potent, cell-permeable HDAC6 inhibitor
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Nexturastat A

Item No. 16874

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[butyl[(phenylamino)carbonyl]amino]methyl]-N-hydroxy-benzamide
CAS Number
1403783-31-2
Molecular Formula
C19H23N3O3
Formula Weight
341.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 15 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/mlEthanol: 1 mg/ml
λmax
240 nm
SMILES
O=C(N(CC1=CC=C(C(NO)=O)C=C1)CCCC)NC2=CC=CC=C2
InChi Code
InChI=1S/C19H23N3O3/c1-2-3-13-22(19(24)20-17-7-5-4-6-8-17)14-15-9-11-16(12-10-15)18(23)21-25/h4-12,25H,2-3,13-14H2,1H3,(H,20,24)(H,21,23)
InChi Key
JZWXMCPARMXZQV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $69

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    1 mg

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    5 mg

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    10 mg

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    Cayman Chemical
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    Product Description

    Nexturastat A is a potent inhibitor of HDAC6 (IC50 = 5.02 nM) that displays high selectivity over all other HDACs.1 It dose-dependently induces hyperacetylation of α-tubulin in B16 murine melanoma cells without elevating histone H3 acetylation.1 Nexturastat A is cell-permeable and inhibits the proliferation of B16 cells (GI50 = 14.3 µM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bergman, J.A., Woan, K., Perez-Villarroel, P., et al. Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth. J. Med. Chem. 55(22), 9891-9899 (2012).