A metabolite of clozapine and muscarinic DREADD agonist
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Clozapine N-oxide

Item No. 16882

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
CAS Number
34233-69-7
Synonyms
  • CNO
Molecular Formula
C18H19ClN4O
Formula Weight
342.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 2 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
214, 260 nm
SMILES
C[N+]1(CCN(C2=NC(C=C(Cl)C=C3)=C3NC4=CC=CC=C24)CC1)[O-]
InChi Code
InChI=1S/C18H19ClN4O/c1-23(24)10-8-22(9-11-23)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
InChi Key
OGUCZBIQSYYWEF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $43

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    Clozapine-N-oxide is a major metabolite of clozapine (Item No. 12059) and an activator of designer receptors exclusively activated by designer drugs (DREADDs) derived from human muscarinic acetylcholine receptors (EC50s = 16.7, 323, 17.4, 18.3, and 18.7 nM for PASMCs expressing hM1-5D receptors, respectively).1,2 It prevents action potential firing in cultured hippocampal neurons transiently expressing hM4D receptors.2 Clozapine-N-oxide increases glutamate in the nucleus accumbens core and inhibits cue-induced reinstatement of cocaine-seeking behavior in rats transfected with hM3Dq DREADD receptors.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Eiermann, B., Engel, G., Johansson, I., et al. The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine. Br. J. Clin. Pharmacol. 44(5), 439-446 (1997).

    2. Armbruster, B.N., Li, X., Pausch, M.H., et al. Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. PNAS 104(12), 5163-5168 (2007).

    3. Scofield, M.D., Boger, H.A., Smith, R.J., et al. Gq-DREADD selectively initiates glial glutamate release and inhibits cue-induced cocaine seeking. Biol. Psychiatry 78(7), 441-451 (2015).