A TRPC3 inhibitor
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Pyr3

Item No. 16888

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[4-[(2,3,3-trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid, ethyl ester
CAS Number
1160514-60-2
Molecular Formula
C16H11Cl3F3N3O3
Formula Weight
456.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 20 mg/mlEthanol: 10 mg/ml
λmax
210, 270 nm
SMILES
O=C(/C(Cl)=C(Cl)/Cl)NC1=CC=C(N2N=CC(C(OCC)=O)=C2C(F)(F)F)C=C1
InChi Code
InChI=1S/C16H11Cl3F3N3O3/c1-2-28-15(27)10-7-23-25(12(10)16(20,21)22)9-5-3-8(4-6-9)24-14(26)11(17)13(18)19/h3-7H,2H2,1H3,(H,24,26)
InChi Key
RZHGONNSASQOAY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $128

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    10 mg

    $186

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    Product Description

    Pyr3 is a pyrazole compound that selectively antagonizes the transient receptor potential canonical channel 3 (TRPC3).1 It inhibits TRPC3-mediated Ca2+ influx with an IC50 value of 0.7 μM without effect on other TRPC members and suppresses activation of nuclear factor of activated T cells with an IC50 value of 0.05 μM.1 Pyr3 has been shown to suppress cardiac hypertrophy in mice at 0.1 mg/kg/day.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kiyonaka, S., Kato, K., Nishida, M., et al. Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc. Natl. Acad. Sci. USA 106(13), 5400-5405 (2009).