An irreversible inhibitor of ornithine decarboxylase
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DL-α-Difluoromethylornithine (hydrochloride hydrate)

Item No. 16889

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(difluoromethyl)-ornithine, monohydrochloride, monohydrate
CAS Number
96020-91-6
Synonyms
  • DFMO
  • Eflornithine
Molecular Formula
C6H12F2N2O2 • HCl [H2O]
Formula Weight
236.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
FC(F)C(C(O)=O)(N)CCCN.Cl.O
InChi Code
InChI=1S/C6H12F2N2O2.ClH.H2O/c7-4(8)6(10,5(11)12)2-1-3-9;;/h4H,1-3,9-10H2,(H,11,12);1H;1H2
InChi Key
FJPAMFNRCFEGSD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $31

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    50 mg

    $53

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    100 mg

    $86

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    500 mg

    $339

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    Cayman Chemical
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    Product Description

    DL-α-Difluoromethylornithine (DFMO) is an irreversible inhibitor of ornithine decarboxylase that suppresses polyamine biosynthesis.1 DFMO displays antiangiogenic and cytostatic effects in tumor cells but must be used in combination with other chemotherapeutic agents to negate compensatory increases in polyamine content through alternate synthesis pathways.1,2,3,4 Through inhibition of polyamine synthesis, DFMO also demonstrates antiparasitic activity in a model of C. parvum infection.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wallace, H.M., Fraser, A.V., and Hughes, A. A perspective of polyamine metabolism. Biochem. J. 376(Pt 1), 1-14 (2003).

    2. Takigawa, M., Enomoto, M., Nishida, Y., et al. Tumor angiogenesis and polyamines: α-Difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits B16 melanoma-induced angiogenesis in ovo and the proliferation of vascular endothelial cells in vitro. Cancer Res. 50(13), 4131-4138 (2014).

    3. Marton, L.J., Levin, V.A., Hervatin, S.J., et al. Potentiation of the antitumor therapeutic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea by α-difluoromethylornithine, an ornithine decarboxylase inhibitor. Cancer Res. 41(11 Pt 1), 4426-4431 (1981).

    4. Hayes, C.S., Burns, M.R., and Gilmour, S.K. Polyamine blockade promotes antitumor immunity. Oncoimmunology 3(1), e27360-27361-e27360-27363 (2014).

    5. Yarlett, N., Waters, W.R., Harp, J.A., et al. Activities of DL-α-difluoromethylarginine and polyamine analogues against Cryptosporidium parvum infection in a T-cell receptor alpha-deficient mouse model. Antimicrob. Agents Chemother. 51(4), 1234-1239 (2007).