A potent, selective inhibitor of PDE7
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BRL 50481

Item No. 16899

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N,2-trimethyl-5-nitro-benzenesulfonamide
CAS Number
433695-36-4
Molecular Formula
C9H12N2O4S
Formula Weight
244.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH7.2) (1:40): 0.02 mg/mlDMSO: 15 mg/mlEthanol: 15 mg/ml
λmax
210, 265 nm
SMILES
CC1=C(S(N(C)C)(=O)=O)C=C([N+]([O-])=O)C=C1
InChi Code
InChI=1S/C9H12N2O4S/c1-7-4-5-8(11(12)13)6-9(7)16(14,15)10(2)3/h4-6H,1-3H3
InChi Key
IFIUFCJFLGCQPH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $49

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    10 mg

    $86

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    25 mg

    $190

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    50 mg

    $329

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    Product Description

    BRL 50481 is a potent, selective inhibitor of phosphodiesterase (PDE) 7, inhibiting human recombinant PDE7A1 with a Ki value of 180 nM.1 It is much less effective against PDE3 and PDE4 and is without effect against PDE1B, PDE1C, PDE2, and PDE5.1 Through its effects on PDE7A1, BRL 50481 enhances the inhibitory effects of the PDE4 blocker rolipram (Item No. 10011132) on monocytes, lung macrophages, and CD8+ T-lymphocytes.1 BRL 50481, at 30 µM, promotes apoptosis in chronic lymphocytic leukemia cells overexpressing PDE7B, suggesting that this compound also acts against PDE7B.2 BRL 50481 can be used to evaluate the role of PDE7 isoforms in intracellular signaling.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

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