A selective M2 receptor allosteric modulator
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Dimethyl-W84 (dibromide)

Item No. 16927

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N1,N6-bis[3-(1,3-dihydro-5-methyl-1,3-dioxo-2H-isoindol-2-yl)propyl]-N1,N1,N6,N6-tetramethyl-1,6-hexanediaminium, dibromide
CAS Number
402475-33-6
Molecular Formula
C34H48N4O4 • 2Br
Formula Weight
736.6
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleWater: soluble
SMILES
CC1=CC=C(C(N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN2C(C(C=C(C)C=C3)=C3C2=O)=O)C4=O)=O)C4=C1.[Br-].[Br-]
InChi Code
InChI=1S/C34H48N4O4.2BrH/c1-25-13-15-27-29(23-25)33(41)35(31(27)39)17-11-21-37(3,4)19-9-7-8-10-20-38(5,6)22-12-18-36-32(40)28-16-14-26(2)24-30(28)34(36)42;;/h13-16,23-24H,7-12,17-22H2,1-6H3;2*1H/q+2;;/p-2
InChi Key
JDKHHBPNUMYHFM-UHFFFAOYSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $156

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    Product Description

    Dimethyl-W84 is a selective allosteric modulator of the M2 muscarinic acetylcholine receptor.1,2 It hinders the dissociation of the orthosteric antagonist N-methylscopolamine from the M2 receptor with an EC50 value of 3 nM.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tränkle, C., Mies-Klomfass, E., Cid, M.H.B., et al. Identification of a [3H]Ligand for the common allosteric site of muscarinic acetylcholine M2 receptors. Mol. Pharmacol. 54(1), 139-145 (1998).

    2. Tränkle, C., Weyand, O., Voigtländer, U., et al. Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors. Mol. Pharmacol. 64(1), 180-190 (2003).