An inhibitor of MMP-13
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CL 82,198

Item No. 16928

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-(4-morpholinyl)butyl]-2-benzofurancarboxamide
CAS Number
307002-71-7
Molecular Formula
C17H22N2O3
Formula Weight
302.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 2.5 mg/mlEthanol: 25 mg/mlPBS (pH 7.2): 0.25 mg/ml
λmax
270 nm
SMILES
O=C(NCCCCN1CCOCC1)C2=CC3=CC=CC=C3O2
InChi Code
InChI=1S/C17H22N2O3/c20-17(16-13-14-5-1-2-6-15(14)22-16)18-7-3-4-8-19-9-11-21-12-10-19/h1-2,5-6,13H,3-4,7-12H2,(H,18,20)
InChi Key
KUJQEQAVMNFFAO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $69

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    10 mg

    $127

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    25 mg

    $297

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    50 mg

    $525

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    Cayman Chemical
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    Product Description

    CL 82,198 is a selective inhibitor of human collagenase-3, also known as matrix metalloproteinase-13 (MMP-13), producing 89% inhibition at 10 µg/ml.1 It is without effect against MMP-1, MMP-9 or TNF-α converting enzyme.1 CL 82,198 is used to evaluate the role of MMP-13 in diverse processes, including cancer cell migration, acute lung injury, and joint degeneration associated with osteoarthritis.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, J.M., Nelson, F.C., Levin, J.I., et al. Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design. J. Am. Chem. Soc. 122, 9648-9654 (2000).

    2. Rath, T., Stöckle, J., Roderfeld, M., et al. Matrix metalloproteinase-13 is regulated by toll-like receptor-9 in colorectal cancer cells and mediates cellular migration. Oncol. Lett. 2(3), 483-488 (2011).

    3. Wohlauer, M., Moore, E.E., Silliman, C.C., et al. Nebulized hypertonic saline attenuates acute lung injury following trauma and hemorrhagic shock via inhibition of matrix metalloproteinase-13. Crit. Care 40(9), 2647-2653 (2012).

    4. Wang, M., Sampson, E.R., Jin, H., et al. MMP13 is a critical target gene during the progression of osteoarthritis. Arthritis Res. Ther. 15(1), 1-11 (2013).