CL 82,198

CL 82,198 is a selective inhibitor of human collagenase-3, also known as matrix metalloproteinase-13 (MMP-13), producing 89% inhibition at 10 µg/ml.¹ It is without effect against MMP-1, MMP-9 or TNF-α converting enzyme.¹ CL 82,198 is used to evaluate the role of MMP-13 in diverse processes, including cancer cell migration, acute lung injury, and joint degeneration associated with osteoarthritis.^2,3,4

WARNING This product is not for human or veterinary use.

1. Chen, J.M., Nelson, F.C., Levin, J.I., et al. Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design. J. Am. Chem. Soc. 122, 9648-9654 (2000).

2. Rath, T., Stöckle, J., Roderfeld, M., et al. Matrix metalloproteinase-13 is regulated by toll-like receptor-9 in colorectal cancer cells and mediates cellular migration. Oncol. Lett. 2(3), 483-488 (2011).

3. Wohlauer, M., Moore, E.E., Silliman, C.C., et al. Nebulized hypertonic saline attenuates acute lung injury following trauma and hemorrhagic shock via inhibition of matrix metalloproteinase-13. Crit. Care 40(9), 2647-2653 (2012).

4. Wang, M., Sampson, E.R., Jin, H., et al. MMP13 is a critical target gene during the progression of osteoarthritis. Arthritis Res. Ther. 15(1), 1-11 (2013).